Tramadol Addiction Tramadol, a painkiller prescribed by a doctor, is available only on prescription. It is a synthetic painkiller that activates mu-opioid brain receptors, the same as Oxycodone or hydrocodone. Tramadol has a lower potential for abuse and addiction than other opioids. However, even when prescribed, Tramadol can still cause problems. What is Tramadol? Tramadol has...